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Glioma Cell Biology

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Title (user) : Glioma Cell BiologyISBN : 9783709114308,9783709114315DOI : 10.1007/978-3-7091-1431-5GoogleBook ID : 1TlpBQAAQBAJEdition : 1Authors (user) : Aleksi Sedo, Rolf Mentlein (eds.)Authors (google) : Aleksi Sedo,Rolf MentleinPublisher :...
Description

Title (user) : Glioma Cell Biology

ISBN : 9783709114308,9783709114315

DOI : 10.1007/978-3-7091-1431-5

GoogleBook ID : 1TlpBQAAQBAJ

Edition : 1

Authors (user) : Aleksi Sedo, Rolf Mentlein (eds.)

Authors (google) : Aleksi Sedo,Rolf Mentlein

Publisher : Springer-Verlag Wien

Language : English

Publication Date : 2014

File Format : pdf

Categories : Medical


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Description (user) :

Gliomas are fatal diseases, but also represent good models for tumor research with the aim to eventually discover new and appropriate therapeutics against this disease. Glioma experimental research models are of help to investigate tumorigenesis (tumor stem cell theory versus "classical" opinions), tumor angiogenesis (since they are highly vascularized) and tumor invasion (since they grow without limits). In addition, they have a very special microenvironment (the brain) and limited tumor stroma cells (mainly microglia and endothelial cells). This book addresses the molecular mechanisms of the various tumor stages, describes the interaction with the tumor microenvironment and furthermore depicts experimental models for Glioma research and future therapeutic concepts. The book is composed and written for Scientists and Medical Doctors in Oncology, Neurosciences and Molecular Biology. ​


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Description (google) :
Gliomas are fatal diseases, but also represent good models for tumor research with the aim to eventually discover new and appropriate therapeutics against this disease. Glioma experimental research models are of help to investigate tumorigenesis (tumor stem cell theory versus "classical" opinions), tumor angiogenesis (since they are highly vascularized) and tumor invasion (since they grow without limits). In addition, they have a very special microenvironment (the brain) and limited tumor stroma cells (mainly microglia and endothelial cells). This book addresses the molecular mechanisms of the various tumor stages, describes the interaction with the tumor microenvironment and furthermore depicts experimental models for Glioma research and future therapeutic concepts. The book is composed and written for Scientists and Medical Doctors in Oncology, Neurosciences and Molecular Biology. ​


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Table of contents :
Front Matter....Pages i-x
Front Matter....Pages 1-1
Cancer Stem Cells and Glioblastoma....Pages 3-22
Epigenetic Changes in Gliomas....Pages 23-45
Signaling Cascades Driving the Malignant Phenotype of Glioma Cells....Pages 47-75
MicroRNAs in the Molecular Pathology of Gliomas....Pages 77-116
Autophagy in Glioma Cells....Pages 117-149
Front Matter....Pages 151-151
Para- and Autocrine Mediators in the Glioma Microenvironment....Pages 153-185
Angiogenesis in Gliomas....Pages 187-219
Immune Response: Glioma-Associated Immunosuppression....Pages 221-239
Microglia in Gliomas: Friend or Foe?....Pages 241-270
Glioma and Extracellular Matrix....Pages 271-292
Glioblastomas and the Special Role of Adhesion Molecules in Their Invasion....Pages 293-315
Glioma-Associated Proteases....Pages 317-395
Front Matter....Pages 397-397
Experimental Models of Glioma....Pages 399-431
Models to Study Glioma Cell Invasion....Pages 433-453
Back Matter....Pages 455-468

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